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Singing the Praises of Unsung Supplements XX: Ipriflavone

Singing the Praises of Unsung Supplements XX: Ipriflavone

Published by Wonder Laboratories on Sep 3rd 2026

Ipriflavone is a supplement you might have never heard of, and it is indeed one that could easily go overlooked. Its name is not recognizable to many consumers of supplements, and it has some pretty specific uses.

What Is Ipriflavone?

Ipriflavone is a semisynthetic supplement that is derived from soy. It is categorized as a semisynthetic isoflavone; isoflavones are water-soluble chemicals found in many types of plants. Ipriflavone has very specific uses, and it has long been used in other countries.  

The primary uses of ipriflavone lie in its bone-supporting properties. It can help mitigate the effects of osteoporosis, and could help mitigate other bone health issues as well. It works in multiple ways. It inhibits the process called bone resorption, whereby bone cells are broken down and released into the blood stream. It also prompts the work of osteoblasts, which are cells that carry out bone formation. 

The bone-supporting properties of ipriflavone are most useful in tandem with calcium, an essential mineral for bones.

Benefits of Ipriflavone

Treating and preventing osteoporosis in postmenopausal women is the foremost use of an ipriflavone + calcium supplement. Studies show that ipriflavone, along with 1000mg of calcium, taken daily helps significantly to reduce the loss of bone density in women with osteoporosis, and it also can work on behalf of people who simply have weak bones. It is very important to take both of these supplements together in order to see this benefit. For this reason, a complex ipriflavone + calcium supplement (containing other minerals as well) is available over the counter. If you or someone you love is a woman moving past menopause, then this supplement should be high on your list of consideration!

Alleviating pain from bone fractures associated with osteoporosis is another potential benefit of ipriflavone. This evidence-supported benefit is an extra reason to keep ipriflavone on hand if you are a postmenopausal woman with osteoporosis.

Otosclerosis tinnitus: Some older research suggests that taking an ipriflavone supplement could also help relieve tinnitus caused by otosclerosis. Otosclerosis is a condition caused over a period of time by abnormal bone remodeling (natural regeneration) in the ear. 

Taking ipriflavone with calcium is extremely important. Calcium is the most important mineral for bones at all stages of life. A major part of ipriflavone’s benefits is its role in supporting the absorption of calcium into bones. A vast amount of the research conducted on ipriflavone is carried out with the use of calcium as well. For these reasons, the ipriflavone + calcium supplement offered here is an ideal way to support bone health, especially for aging women after the stage of menopause.

The benefits of ipriflavone combined with calcium are clear. Anyone who believes they might benefit from adding an ipriflavone + calcium oral supplement to their daily regimen should first talk it over with their personal physician or other licensed healthcare professional knowledgeable of supplements.

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