How Do Ketones and Ketone Bodies Benefit Health?

How Do Ketones and Ketone Bodies Benefit Health?

Published by Wonder Laboratories on Oct 2nd 2019

Most of us who have participated in endurance sports such as running or biking have heard about how the consumption of carbohydrates hours before an event can provide an extra dose of energy during the event. While burning carbs can produce the glucose that fuels our bodies, it might surprise you to know there is an alternative source of energy for the body, and it involves burning body fats and the use of compounds known as ketones and ketone bodies.

What Is Ketogenesis?

By now, you might have heard about the process of ketogenesis, which is the basis of the popularized ketogenic diet, which is based on the premise that fasting combined with significantly reduced intake of carbs can kick start ketogenesis. This is a biochemical process in which your body will break down fatty acids stored in your body, eventually producing an alternate source of energy typically accompanied by weight loss and other health benefits. Per, reaching a state of ketosis is achieved by a depletion of glycogen and blood sugar engineered by limiting carbohydrates to less than 5 percent and protein to 20-25 percent of your daily consumption of macronutrients. Fasting and exercise can also play a role in depleting your glycogen stores. It's a process that within the first few days will result in a temporary dip in energy, focus, and exercise performance as well as bad breath (a fruity or nail-polish like smell) as you reach what's called a state of ketosis. After that, though, you will emerge on the other side with an assortment of benefits ranging from improved brain function and enhanced skin condition to better blood sugar levels and reduced cravings for food, per

Ketones and Ketone Bodies

Ketones, per National Institutes of Health (NIH), are relatively simple compounds composed of hydrogen, carbon, and oxygen. These are what fuel the body when fat is being metabolized as an energy source in the absence of carbohydrates. That works to help you reach your goal of losing weight – assuming that is what you aspire to do. Ketones also have many uses outside of health considerations: they are one of the chemical ingredients used in making explosives, paints, and textiles. They have also been used in both natural and synthetic pharmaceutical products, such as antibiotics and steroid hormones (cortisone), per Ketone bodies, water-soluble compounds often regarded synonymously to ‘ketones,' are produced naturally in the liver by the breakdown of fats, and these can include acetone (the source of your keto breath), acetoacetic acid, and beta-hydroxybutyric acid, per To put it more succinctly, ketone bodies are an alternative source of fuel the body can use for energy, and ketones are what gets created from the breakdown of your fat stores.

Ketosis Process Summarized

Here's a quick review of how the process works that gets you in a state of ketosis, ready to take full advantage of your ketogenic diet, per
  • Starve your body of carbohydrates and deplete your glycogen stores (source of glucose).
  • When glycogen is gone, your insulin and blood sugar levels drop.
  • With no sugars available as energy sources, your body turns to fat for an alternate energy source.
  • As your body breaks down fats, ketone bodies are produced by oxidization, placing you in a state of ketosis. You now have a higher level of beneficial ketones flowing through your body.

Health Benefits of Ketones

First, be sure to discuss ketones, ketone bodies, and the ketogenic diet with your physician before starting such a diet, even if it means you end up being advised against doing it for whatever reason:
  • Fat loss. Self-explanatory, presumably accompanied by weight loss.
  • Diabetes benefits. Per, a low-carb, high-fat diet can possibly reverse insulin and type 2 diabetes.
  • Decrease inflammation. Various studies have demonstrated that the body's transition from glucose to ketone body metabolism activates anti-inflammatory mechanisms in the body, per
  • Improve cognitive function. A study of more than 150 subjects with Alzheimer's disease showed that intake of an oral ketone supplement improved cognition, per
  • Reduce food cravings. Although ghrelin, known as the hunger hormone, tends to rise during weight loss, thus increasing food cravings, a study cited at indicated that such an increase in ghrelin was suppressed in people in the midst of the ketogenic diet.
  • Chronic metabolic conditions. A low-carb diet has been shown to possibly alleviate obesity risk factors, such as high blood pressure, per
  • Cardiovascular benefits. A study of obese subjects cited at found that a sub-20-gram ketogenic diet not only reduced total cholesterol, LDL ( bad ) cholesterol, and triglycerides, it also raised HDL ( good ) cholesterol.

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